Insulinomatosis/NIPHS

What is Insulinomatosis or noninsulinoma pancreatogenous hypoglycaemia (NIPHS)?

Insulinomatosis or NIPHS

An insulinoma is a rare type of functional neuroendocrine tumour which produces insulin and causes hypoglycaemia. A small number of people who complete the diagnosis process for an insulinoma are diagnosed with related conditions:

• Insulinomatosis: multiple insulinomas including micro-insulinomas

• Proinsulinoma: neuroendocrine tumour which produces proinsulin

• Noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS): beta cells in the pancreas produce excess insulin without forming a tumour
  
  

  Useful information:
  
  

• 2006 Islet Hyperplasia in Adults: Challenge to Preoperatively Diagnose Non-Insulinoma Pancreatogenic Hypoglycemia Syndrome

• 2017 Proinsulinomas systematic review

• 2019 MEN1 update

• 2020 GLP-1R imaging

• 2021 GLP-1R imaging

• 2023 ENETS guidance

• 2023 Insulinomatosis new aspects

• 2023 NIPHS literature review
  
  If you have been diagnosed with one of these very rare conditions, please join our Facebook group. Insulinomatosis or noninsulinoma pancreatogenous hypoglycaemia (NIPHS) | Facebook